Estimation of Ceraluplasmin (CER) and Alpha- 1 Antitrypsin (AAT) levels among hepatitis patients in acute and chronic state

  • Abdul Hussien M.K. Aljebory Babylon university Clinical chemistry
  • Talib abdulhussien Mussa Almuthanna university biochemistry
  • Shakir Hamaad M. Raheem Tuama Babylon Public Health Lab, Clinical Immunology
Keywords: Hepatitis B and C, Ceraluplasmin, Alpha -1 antitrypsin, Single Radial Immunodiffusion Assay


Hepatitis Viruses are a common cause of viral hepatitis, it has a wide distribution among peoples, it has more than five common types: Hepatitis A, B, C, D, E. The level of Ceraluplasmin and alpha- 1 antitrypsin differences in acute and chronic hepatitis, it may be normal or mild increased in acute hepatitis while is decreased in chronic hepatitis patients. And the aim of this study to find out the relationship between the frequency of hepatitis and the concentration of immunochemical protein (such as Ceraluplasmin and Alpha -1 antitrypsin) present in patients during the acute and chronic periods of hepatitis infections. The total number of 36 patients with hepatitis (B) and 30 patients with hepatitis (C) viral infection with an age range (22- 55 years) were enrolled in this study. Patients who had liver cirrhosis was excluded from this study. With a total number of 24 age matched apparently healthy control group was taken to be compared with case studies. Assessment of serum levels of Ceraluplasmin and α-1 Antitrypsin were done by the Single Radial Immunodiffusion Assay to both case study and control group in Babylon public health laboratory from June to September 2007. The our result shows no significant (N.S) increased in level of up-1 Antitrypsin among acute patient in both types (B and C) While there is a highly significant (H.S.) result for chronic patients also in both types (B and C). Ceraluplasmin level show (N.S.) decreased among acute patient while there decreases ( H.S. ) In both groups of patients (B and C) after compared with a control sample. This result with agreement with many universal results.