The Role of Protein Tyrosine Phosphatase Nonreceptor Type 22 Gene polymorphism in Patients With Type 1 Diabetes Mellitus.
Keywords: T1DM, Genetic, Protein tyrosine phosphatase nonreceptor type 22, Polymorphism, Genotype, Allele
AbstractBackground: Type 1 diabetes mellitus (T1DM) is an autoimmune multifactorial disease characterized by progressive destruction of pancreatic beta cells by genetic and environmental factors which leads to an absolute dependence of insulin for survival and maintenance of health. Materials and methods: One polymorphic sites of PTPN22 gene was genotyped in 64 patients with T1DM, and 25 healthy controls. Genotypes were determined by the polymerase chain restriction fragment length polymorphism (PCR-RFLP) method. Results: The single nucleotide polymorphisms T/T, of the PTPN22 gene may be participate in the susceptibility of T1DM in the Iraqi population. Conclusion: Although PTPN22-T/T polymorphism not associated with T1DM in many population, our study confirmed significant correlation between PTPN22 and T1DM.