Causes of Antibacterial Resistance in Some of Enteropathogens Isolated from Colon Cancer Patients in Al-Dewaniyah Governorate.
Background: Bacterial infections associated with multidrug resistance have been implicated in high mortality and morbidity reported among cancer patients.
Objective:To detect the causes of β-lactamase resistance inEscherichia coli and Klebsiella spp. isolated from colon
Methods: Twenty -eight stool samples from colon cancer patientssamples ,in addition to that, 25 samples were collected from control group (healthpersons). Samples were labeled and transported to the laboratory in portable containerthenstreaked on MacConkey agar and incubated at 37˚C for 24 hours under aerobic condition. The antimicrobial susceptibility testing was done by the agar discs diffusion method. Results: out of 28 samples from colon cancer patients, the results showed that 26 (92.8 %) of stool were positive for culture. The study revealed thatKlebsiellasp.and E. coli were the most common isolated species. The results showed that the vast majority of isolates were found to be resistant to ß-lactam antibiotics (ampicillin and amoxicillin) .
Conclusion and Recommendation:All of the tested E. coli andKlebsiellaeisolates are multidrug resistant; therefore, such organisms represent a serious therapeutic challenge in cancer patients.