Single Serum Progesterone Measurement in Pregnancy Prognosis
Aim of the study: To assess the value of single serum progesterone in diagnosis of viable, ectopic and failing pregnancy.
Patients and methods: This cross sectional study was done in Al Basra general hospital and Al Basra maternity and child hospital from June 2013 through January 2014. The study included 64 patient, all have 1st trimester vaginal bleeding and/or abdominal pain. From each patient a 5 cc blood sample was obtained for assessment of progesterone and β-HCG, and then patients were sent to ultrasound examination.
Result: Mean age of women enrolled in the present study was 31.21± 4.23 years and it ranged from 20 to 35 years. Mean gestational age was 8.30 ±2.15 and it ranged from 6 to 12 weeks. Ultrasound examination revealed that 36 patients (56.3%) had viable pregnancy, 18 patients (28.1 %) had failing pregnancy and 10 patients (15.6%) had ectopic pregnancy. Mean serum progesterone in women with viable, failed and ectopic pregnancies was 20.01 ± 1.7 ng/ml, 9.09 ± 8.2 ng/ml and 19.7± 16.3 ng/ml. The sensitivity and specify of single serum progesterone measurement in diagnosis of pregnancy failure in this study were 72.2% and 66.6%, respectively while those of serum β-HCG were 95.4% and 98.1%.
Conclusion: Single serum progesterone is not of significant value in predicting pregnancy outcome.