Spectrophotometric determination of Valsartan in pure form and in its pharmaceutical preparations
Keywords:
spectrophotometric, Valsartan, NBD-Cl
Abstract
An easy, rapid and economical spectrophotometric method for determination of Valsartan (Val), by reaction with 4-chloro-7-nitrobenzofurazan (NBD-Cl) as reagent in an alkaline interemediate. This method is based on the forming of product between (Val) and the chromogenic reagent (NBD-Cl), to produce a brown color at (pH 11.9) and λmax. 470 nm. Beer’s Law is obeyed at the concentrations range of (0.4-14.8 µg/ml), with molar absorptivity of (1.05×104 L/mol.cm) and correlation coefficient 0.9827, The limit of detection was 0.557 µg/ml. The suggested method was prosperity implement to the determination of (Val) in pure form and in its pharmaceutical formulations (tablets).
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References
[1] American Society of Health-System Pharmacists, "Valsartan Monograph for Professionals". Drugs.com.. Retrieved 3 March 2019.
[2] British pharmacopoeia, 7th edition, pharm. Press London, 2013.
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[9] P. E. Erden, I. H. Tasdemir, C. Kacar, E. Kilic, “Simultaneous determination of Valsartan and Amlodipine Besylate in human serum and pharmaceutical dosage forms by voltammetry”, International Journal of Electrochemical Science, 2014; 9(5): 2208-2220.
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[11] G. S. Rao, S. V. Rao, S. V. M. Vardhan and D. Ramachandran, “Development and validation of new UV- spectrophotometric assay method for Valsartan in pure and in formulations”, Journal of Chemical and Pharmaceutical Research, 2013; 5(7): 229-232.
[12] A. O. Elbashir, “Utilization of 4-Chloro-7-Nitto-benzo-2-Oxa-1, 3-Diazol (NBD-CL) as Chromogenic Reagent for Determination of Metformin hydrochloride (MET) in Pharma-ceutical Formulation”, Asian Journal of Pharmaceutical Research and Development, 2019; 27: 19-23.
[14] O. Armagan, “Spectrophotometric and spectrofluorimetric determination of some drugs containing secondary amine group in bulk drug and dosage forms via derivatizationwith 4-Chloro-7-nitrobenzofurazan”, International Year of Chemistry, 2011; 34(4): 677-682.
[15] M. G. Kassem, I. A. Darwish and H. W. Darwish, “Highly sensitive fluorimetric method for determination of Varenicline in its bulk and tablets via with 7-Chloro-4-nitrobenzoxadiazole”, Digest Journal of Nanomaterials and Biostructures, 2014; 9(3): 1065-1075.
[16] O. Tamadr and A. Abdalla, “Spectrophotometric method for determination of Gabapentin in pharmaceutical formulation by derivatization with 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl)”, International Journal of Drug Development and Research, 2015; 7(4).
[2] British pharmacopoeia, 7th edition, pharm. Press London, 2013.
[3] N. Anjaneyulu, R. Naga Kishore, M. Ravi Kumar and G. Sneha, “Development and Validation of A RP- HPLC Method for the Simultaneous Estimation of Valsartan and Sacubitril in Rat Plasma”, Glob J Pharmaceu Sci, 2018; 6(5): 1-6.
[4] B. U. Rao and A. P. Nikalje, “Simultaneous determination of Valsartan and Hydrochlorothiazide in a tablet dosage form by liquid chromatography”, African Journal of Pharmacy and Pharmacology, 2014; 8(38): 953-961.
[5] A. M. A. Alamein, “Validated Eco-Friendly chromatographic methods for simultaneous determination of Sacubitril and Valsartan in spiked human plasma and in pharmaceutical formulation”, Journal of Applied Pharmaceutical Science, 2018; 8(02): 011-017.
[6] K. A. M. Attai, M. W. I. Nassar, A. El-Olemy, S. Ramzy, “Application of TLC-Densitometric method for simultaneous determination of Sacubitril and Valsartan in their newly approvedpharmaceutical formulation”, Eurasian Journal of Analytical Chemistry, 2018; 13(6).
[7] N. J. Shah, B. Suhagia, R. R. Shah, N. M. Patel, “HPTLC method for the simultaneous estimation of Valsartan and Hydrochlorothiazide in tablet dosage form”, Indian Journal of Pharmaceutical Sciences, 2009; 71(1).
[8] A. Z. Al-Hafidh, A. T. Al-Taee, “Electrochemical behavior of Valsartan, Glibenclamide and their interaction with each other using sqauare wave voltammetry”, Raf. J. Sci. 2019; 28(2): 64-75.
[9] P. E. Erden, I. H. Tasdemir, C. Kacar, E. Kilic, “Simultaneous determination of Valsartan and Amlodipine Besylate in human serum and pharmaceutical dosage forms by voltammetry”, International Journal of Electrochemical Science, 2014; 9(5): 2208-2220.
[10] M. L. Jadhav, M. V. Girase, S. K. Tidme and M. S. Junagade, “Development and validation of spectrophotometric methods for simultaneous estimation of Valsartan and Hydrochlorothiazide in tablet dosage form”, International Journal of Spectroscopy, 2014; (2014).
[11] G. S. Rao, S. V. Rao, S. V. M. Vardhan and D. Ramachandran, “Development and validation of new UV- spectrophotometric assay method for Valsartan in pure and in formulations”, Journal of Chemical and Pharmaceutical Research, 2013; 5(7): 229-232.
[12] A. O. Elbashir, “Utilization of 4-Chloro-7-Nitto-benzo-2-Oxa-1, 3-Diazol (NBD-CL) as Chromogenic Reagent for Determination of Metformin hydrochloride (MET) in Pharma-ceutical Formulation”, Asian Journal of Pharmaceutical Research and Development, 2019; 27: 19-23.
[14] O. Armagan, “Spectrophotometric and spectrofluorimetric determination of some drugs containing secondary amine group in bulk drug and dosage forms via derivatizationwith 4-Chloro-7-nitrobenzofurazan”, International Year of Chemistry, 2011; 34(4): 677-682.
[15] M. G. Kassem, I. A. Darwish and H. W. Darwish, “Highly sensitive fluorimetric method for determination of Varenicline in its bulk and tablets via with 7-Chloro-4-nitrobenzoxadiazole”, Digest Journal of Nanomaterials and Biostructures, 2014; 9(3): 1065-1075.
[16] O. Tamadr and A. Abdalla, “Spectrophotometric method for determination of Gabapentin in pharmaceutical formulation by derivatization with 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl)”, International Journal of Drug Development and Research, 2015; 7(4).
Published
2021-07-31
How to Cite
Rashid, Q., & Ruwaida Farman Salih. (2021). Spectrophotometric determination of Valsartan in pure form and in its pharmaceutical preparations . Al-Qadisiyah Journal of Pure Science, 26(4), 239–246. https://doi.org/10.29350/qjps.2021.26.4.1317
Section
Special Issue (Silver Jubilee)
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