the Study of some histopathological changes occurring in white laboratory mice infected with Cutaneous Leishmaniasis in Al – diwaniyah province, Iraq.
Abstract
Leishmaniasis is caused by an intracellular parasite . It is endemic in Asia, Africa, the Americas, and the Mediterranean region. Worldwide, 1.5 to 2 million new cases occur each year .The histological study of the liver tissue of white laboratory mice (Mus musculus) infected with L. major a parasite showed The presence of severe steatosis of hepatocytes Hepatocyte degeneration, And loss of the radial arrangement of hepatocytes, With heavy infiltration in inflammatory cells, especially phagocytes( Macrophage) with Hyperplasia and congestion of the bile duct . As for histological sections of skin lesions taken from ear , Foot , tail ، were showed epidermal ulcerative , Accompanied by severe leaching of the dermis layer neutrophil ,polymorph lymphocytes ، with hemorrhage of the dermis, with necrosis of the epidermal cells of all skin lesions in the ear, foot and tail.
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on the parasite Leishmania tropica ex vivo and in vivo Master's thesis, College of Science, University of Baghdad: 116 pages.
Al-Abbas, W. D. Sh. (2017). A comparative study to evaluate the effectiveness of Iraqi propolis extract and camel milk on the viability of the visceral parasite Leishmania donovani and its investigation in the sand fly vector (Diptera: Phlebotomus) using polymer chain reaction technique PCR. PhD thesis, College of Science, University of Kufa.
Al-Abdullah, Sh. (2012). Physiology, first edition. House of the March for Publishing and Distribution, Amman, Jordan. The number of pages of the book is 534.
Akhoundi, M., Kuhls, K., Cannet, A., Votýpka, J., Marty, P., Delaunay, P. and Sereno, D. (2016). A historical overview of the classification, evolution, and dispersion of Leishmania parasites and sandflies. PLoS neglected tropical diseases 10(3).
Arfan, B. and Rahman, S. (2006). Correlation of clinical histopathological, and microbiological finding in 60 cases of cutaneous leishmaniasis. IJDVL., 72: 28-32.
Bifeld, E. and Clos, J. (2015). The genetics of Leishmania virulence. Medical microbiology and immunology 204(6), 619-634.
Blum, J., Lockwood, D.N., Visser, L., Harms, G., Bailey, M.S., Caumes, E., Clerinx, J., van Thiel, P.P., Morizot, G. and Hatz, C. (2012). Local or systemic treatment for New World cutaneous leishmaniasis? Re-evaluating the evidence for the risk of mucosal leishmaniasis. International health 4(3), 153-163.
Karamian, M., Kuhls, K., Hemmati, M. and Ghatee, M.A. (2016). Phylogenetic structure of Leishmania tropica in the new endemic focus Birjand in East Iran in comparison to other Iranian endemic regions. Acta Tropica 158, 68-76.
Kaye, P. and Scott, P. (2011). Leishmaniasis: complexity at the host–pathogen interface. Nature reviews microbiology 9(8), 604-615.
Kurban, A.; Malak, J.; Farah, F. and Chaglassian, H.(1966). Histopathology of cutaneous leishmaniasis. Arch. Derm., 3: 396-401.
Mcgwire, B.S. and Satoskar, A. (2014). Leishmaniasis: clinical syndromes and treatment. QJM: An International Journal of Medicine 107(1), 7-14.
Postigo, J.A.R. (2010). Leishmaniasis in the world health organization eastern mediterranean region. International journal of antimicrobial agents 36, S62-S65.
Sangueza, O., Sangueza, J., Stiller, M. and and Sangueza, P.(1983). Mucocutaneous leishmaniasis: A clinicopathologic classification. J. Am. Acad. Dermatol., 28: 927-931.
Santos Jamile Prado dos , Leucio Câmara Alves , Rafael Antonio Nascimento Ramos. and Aparecida da Gloria Faustino.(2013). Histological changes and immunolabeling ofLeishmania infantum in kidneys and urinary bladder of dogs. Rev. Bras. Parasitol. Vet. vol.22.
World Health Organization Regional Office for Africa, (2017). Leishmaniasis [WWW Document]. http://www.afro.who.int/health-topics/Leishmaniasis.
World Health Organization WHO (2010). Factsheet338. Medicines: rational use of medicines. Geneva: WHO, Available at http://www.who. int/ mediacentre/ factsheets/ fs338/en.
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