Synthesis of fused dihydrobenzo [4,5]imidazo[1,2-a]pyrmido[5,4-e]pyrmidin-3(4H)-amine derivatives

  • hamid mohammed mustansiriyah univeristy, college of science, department of chemistry
  • Fadhel R. Hafedh
  • Zainab N. Mageed
Keywords: pyrmidines, benzimidazole

Abstract

Abstract

  Some of fused dihydrobenzo [4,5]imidazo [1,2-a] pyrmido [5,4-e] pyrmidin-3(4H)-amine  derivatives were synthesized,  theses derivatives derived from 4-amino-2-(4-chloro or bromophenyl) -1,2-dihydropyrimido[1,2-a] benzimidazole-3-carbonitrile (4,5), which prepared by reaction 1H-benzimidazol-2-amine (1) and p-chlorobenzaldehyde or p-bromobenzaldehyde (2)  and malononitrile (3). These derivatives prepared by reaction compound (4,5) with with triethylorthoformate in presence acetic anhydride to give the products (6,7), then the products was reacted with aliphatic amines (hydrazine, methyl amine, ethyl amine, propyl amine and isobutyl amine) to give pyrmidin rings (8-17) respectively. All these derivatives characterization by FT-IR , HNMR spectra and physical properties.

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References

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Published
2021-07-05
How to Cite
mohammed, hamid, Fadhel R. Hafedh, & Zainab N. Mageed. (2021). Synthesis of fused dihydrobenzo [4,5]imidazo[1,2-a]pyrmido[5,4-e]pyrmidin-3(4H)-amine derivatives . Al-Qadisiyah Journal of Pure Science, 26(4), 35–44. https://doi.org/10.29350/qjps.2021.26.4.1371
Section
Special Issue (Silver Jubilee)