Naproxen Sodium Release from Poly(acrylic acid-co- N-vinyl-2-pyrrolidone) Hydrogels

  • Nadher D. Radhy Department of Chemistry pharmaceutical, College of pharmacy, University of Al-Qadissiya
Keywords: hydrogels, acrylic acid, N-vinyl-2-pyrrolidone, swelling ratio, Naproxen Sodium, drug release

Abstract

Copolymer hydrogels of acrylic acid (AA) and N-vinyl-2-pyrrolidone (NVP), crosslinked with 1,4-butanediol dimethacrylate (BDDMA), were prepared by radical copolymerization. The chemical structures of copolymer hydrogels were analyzed by Fourier transform infrared spectrometer (FTIR) and H NMR spectroscopy. The swelling ratio (Rs) was measured for four types of hydrogels structures, in three different media pH 1.2 , 4 and 7.4 at 370C as a function of time. A Naproxen Sodium is used as a model drug to investigate the drug release profile of the hydrogels. The concentration of drug released was measured on UV-Vis spectrophotometer. Results indicated that the swelling ratio and drug release is increase concentration decrease of crosslinked agent and pH increase.

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Published
2018-07-30
How to Cite
D. Radhy, N. (2018). Naproxen Sodium Release from Poly(acrylic acid-co- N-vinyl-2-pyrrolidone) Hydrogels. Al-Qadisiyah Journal of Pure Science, 21(1), 64 - 76. Retrieved from https://journalsc.qu.edu.iq/index.php/JOPS/article/view/41
Issue
Vol 21 No 1 (2016)
Section
Articles

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