Effect of Metformin on some physiological parameters in patients of diabetes in Diwaniyah General Hospital
Keywords:
Type 2 diabetes mellitus, metformin, liver enzymes (ALT,AST),Blood urea
Abstract
The study aims to determine the effect of Metformin on some certain criteria in patients with type2 diabetes. Twenty five newly diagnosed type2 diabetic patients participated in this study. Ages ranged between 35-65years. Blood samples were taken from people infected before treatment and after three months of Metformin give them the drug dose (500 mg / day) twice a day and were compared with 25 people from a group of healthy control group. Then blood analysis for the purpose of measuring the level of cholesterol, triglycerides, lipoprotein high for density HDL, lipoprotein low for density LDL, liver enzymes (ALT, AST) and blood urea .The results showed a significant rise in the metformin group (before treatment) and the control group in cholesterol levels and triglycerides and lipoprotein low for density and a significant decrease in lipoprotein level of high density. The significant decrease in the level of cholesterol, triglycerides and lipoprotein low for density and high moral in high-density lipoprotein level range between Metformin group (after treatment) compared with Metformin group (before treatment) and the control group. Note also been a significant increase in liver enzyme levels compared between groups (after treatment) and (before treatment) and the control group.Downloads
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References
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glucose by decreasing hepatic production in healthy volunteers
without increasing carbohydrate oxidation Am. J. med. Sci. 309(3): pp.134-139.
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diagnosis and treatment. International edition. NewYork: Lange
Medical.1203-1215.
26-Yenigun, M. 1997. Cardiovascular diabetes. Istanbul University Printing HouIstanse, bul, Turkey.
27- Yki-Jarvinen, H ; Ryysy, L.;& Nikkila, K, 1999. Comparison of bed
time Insulin regimens in patients with type 2 diabetes
mellitus .Arandomized controlled trial. Annals of internal
medicine.130: 389-96.
On serum lipid profile in hyperlipidemic rats medical .J.of Babylon.10(1).
2- Al-Mola, I.T & Ahmed, F.A, 2006. The effect of metformen on some liver
function tests in type2 diabetic patients.Irq.J.pharm.6(1):25-27.
3- Al-Naeaimy.K.S, 2011. Comparative effect of Metformen and Glibenclamide
on lipid profile in type2 diabetic patients.Tikrit Journal of
Pharmaceutical Sciences.7(1):46-50.
4- Al-Thanoon, Z.A; Mahmood, I.H and AbdulJabbar, I, 2013. Effects of
metformin alone or in combination with vitamin C and E on serum
glucose concentration and lipid profile in type2 diabetic patients.
Tikrit.J.Pharm.Scie.9(2):193-201.
5- American Diabetes Association screening for type 2 diabetes. Clinical practice
Recommendations.2004.Diabetes care, 27(suppll):11-14.
6- Bordenave, S.; Brandou, F.; Manetta, J.; Fédou, C.; Mercier, J. and Brun, J.
F, 2008. Effects of acute exercise on insulin sensitivity, glucose
effectiveness and disposition index in type 2 diabetic patients. J. Diab.&
Metabol. 34(3): 250-257.
7- Eberhart, M.S.; Ogden,C.;Engelgan, M.; Cadwell,B. and Saldah, S.H, 2004.
Prevalence of overweigt and obesity Among Adults with diagnosed
Diabetes. Centers for disease.(45):1066-1068.
8- Friedewald, W.T;Levy, R. and Frederickson, D.S.(1972). Estimation of low density
lipoprotein in plasma without use of the preoperative ultracentrifuge.
Clin.Chem.18:499-502.
9-Ginsberg, H.; Plutzky, J.& Sobel,B.E, 1999. Areview of metabolic and
cardiovascular effects of oral antidiabetic agents beyond
glucose level lowering.Journal of Cardiovascular risk.6:337-46.
10- Gregorio, F.; Ambrosi, F.; Cristallini, S.; Pedetti, M.; Filipponi, P. and Santeusanio, F, 1992. Therapeutical concentrations of metformin, glibenclamide, gliclazide gliquidone at differentglucose levels: Invitro effects on pancreatic A- and B- cell unction. Diabetes. Res. Clin. Practice. 18: pp.197-206.
11- Groop, L.C. 1992. Sulfonylureas in NIDDM. Diabetes Care. 15: pp.737- 745
12- Harris, E. H. 2005.Elevated liver function tests in type 2 diabetes.
Clinical Diabetes. 23(3): 115-119.
13- Johnson, A.; Chan, J.C; Rydberg, T.; Vaaler, A.; Hallengren, B.
Cockram, C.S. Critchley,J.A.& Melander,A.2000
Pharmacodynamics and pharmacokinetics of intravenoun
metformin in cascasian and chines patients with type 2 diabetes.
Eur.J.Clin.Pharmacol. 55(10):pp.721-727.
14- Karimzadeh, M. A.; Eftekar, M.& Taheripanah, R, 2007.The effect of
administration opf metformin on lipid profile changes and
insulin resistance in patient with polycystic ovary syndrome.
Middle East Fertility Society Journal. 12 (3): 174-178.
15-Kasia,J.L ; Clifford, J.B and Silvio, E. I. 2011. Use of Metformin in the
Setting of Mild-to-Moderate Renal Insufficiency. Diabetes Care
J.34(6):1431-1437.
16- Limayeet, P. V.; Raghuram, N. and sivakami, S, 2003. Oxidative stress and gene expression of an enzymes in the renal cortex of streptozoto induced diabetic rats. J. Mol., and cellu, Bioch, 243: 147-152.
17-NIDDK, (National Institute of Diabetes and Digestive and Kidney). 2009. Diseases. High Blood Pressure and Kidney Disease. Link. Accessed: November 3, 2009.
18-Rains, S.G.; Wilson,G.A. & Richmond,W. 1988. The effect of
Glibenclamide and metformin on serum lipoprotein in type 2
diabetes. Diabetic medicine,5:653-8.
19- Rother, K.I. 2007.Diabetes treatment.Bridging the Divide. N Eng.J.Med.356(15):1499-1501.
20-Salsali,A. & Nathan, M. 2006. Areview of types 1 &2 diabetes mel
litus and their treatment with insulin .J.Am.Ther.13(4):349-355.
21-Santana, L. F; Sa M. F.; Ferriani, R. A. de Moura M. D; Foss, M. C.and
Reis, R. M. 2004. Effect of metformin on the clinical and
metabolic assessmenmt of womwn with polycystic ovary
syndrom. Gynecol. Endocrinol., 19: 86-96.
22-Simon, H.; Cannistra, S. A.; Etkin, M. j.; Godine, J. E.; Huang, E.; Heller, D.; Shellito, P. C. and Stern, T. A. 2002. Diabetes Diet. Nidus Information Services. New York.U.S.A.
23-Slesnolfi,B. 1990. Characterization and significance of sulphonyl urea receptors. Diabetes care3(suppl):2-8.
24-Tayek, J.A. 1995. Low-Dose oral glyburide reduces fasting blood
glucose by decreasing hepatic production in healthy volunteers
without increasing carbohydrate oxidation Am. J. med. Sci. 309(3): pp.134-139.
25- Tierney, L.M; Mcphee, S.J. and Papadakis, M.A. 2002. Current medical
diagnosis and treatment. International edition. NewYork: Lange
Medical.1203-1215.
26-Yenigun, M. 1997. Cardiovascular diabetes. Istanbul University Printing HouIstanse, bul, Turkey.
27- Yki-Jarvinen, H ; Ryysy, L.;& Nikkila, K, 1999. Comparison of bed
time Insulin regimens in patients with type 2 diabetes
mellitus .Arandomized controlled trial. Annals of internal
medicine.130: 389-96.
Published
2018-01-26
How to Cite
A. Alsudani, A. (2018). Effect of Metformin on some physiological parameters in patients of diabetes in Diwaniyah General Hospital. Al-Qadisiyah Journal of Pure Science, 22(3), 89 - 97. Retrieved from https://journalsc.qu.edu.iq/index.php/JOPS/article/view/600
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