Synthesis, Characterization and Biological Activity of some new phthalimides and maleimides derivetives containing benzothiazole ring

  • Muhanned A. Mahmoud Department of Chemistry ,College of Science for Women ,University of Baghdad
  • Atyaf Qusay Kadhim Department of Chemistry ,College of Science for Women ,University of Baghdad
  • Ahmed Younus Abed* Department of Chemistry ,College of Science for Women ,University of Baghdad*

Abstract

In this work, a series of new3-nitro phthalimides and   bromo maleimides  derivetives containing benzothiazole ring were  synthesized, the Synthesis  of series of N-(substituted benzothiazole-2-yl) 3-nitro phthalimide were  performed  via  three steps,  the  first  one  involved  preparation  of  a  series  of substituted  2-aminobenzothiazole  via  reaction  of  different  primary  aromatic amines with ammonium thiocyanate and bromine in glacial acetic acid, In the second step the prepared amino benzothiozoles were introduced in reaction with 3- nitro phthalic anhydride producing a series of N-(substituted benzothiazole-2-yl) 3- nitro phthalamic acid, while  Fusion Method used in preparation  of  a  series   N-(substituted benzothiazol-2-yl) bromo maleimide via Fusion The prepared substituted 2-aminobenzothiazole with Bromo Maleic anhydride to producing a series of N-(substituted benzothiazol-2-yl) bromo maleimide ,the synthesized compounds were identified depending upon physical and spectral method, Microbiological activities  of  the   prepared   compounds   against    four  types  of  bacteria and one type of  fungi  were  evaluated  and  the results showed  that the most  tested compounds have good antibacterial and anti fungi  activity .

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Published
2018-04-09
How to Cite
A. Mahmoud, M., Qusay Kadhim, A., & Younus Abed*, A. (2018). Synthesis, Characterization and Biological Activity of some new phthalimides and maleimides derivetives containing benzothiazole ring. Al-Qadisiyah Journal of Pure Science, 22(1), 177 - 191. Retrieved from https://journalsc.qu.edu.iq/index.php/JOPS/article/view/709
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Articles