Assessment of Lipoprotein and Histopathological Changes of Male Rats Rattus norvegicus Treated With Formaldehyde

Abstract

The present study was designed for detection the effect of formaldehyde in some biochemical and physiological parameters which included cholesterol , triglycerides  and level of lipid profile and histopathological changes of some organs of the laboratory male rats  Rattus norvegicus , thirty two of rats were divided into four groups , the first group administrated normal saline as control group while the three others groups administrated formaldehyde orally (10mg/kg body weight/day) for one , two and three months respectively .                                                                                                                         The results showed a significant increasing (P≤0.05) in level of cholesterol , LDL and VLDL in second, third and fourth groups compared with control group, while non-significant increasing in triglycerides and atherogenic index level for treated groups (second, third and fourth groups) compared with control group . Significant decreasing (P≤0.05) was observed in level of HDL for all treated groups by formaldehyde compared with control group .                                                                   Also, the results showed histopathological changes as congestion , destroyed and thickness the walls of alveoli , hemorrhage and infiltration of inflammatory cells in lung . In addition to many damages in liver which included congestion of central vein , necrosis , enlargement of sinusoids , inflammation , hemorrhage and vacuolation of hepatocytes with hypertrophy the nuclei of its