Study the effect of obesity on the level of adiponectin and DNA damage in obese patients with type2 diabetes in Wasit Province

Abstract

The study present was conducted on 36 patients of both sexes with diabetes type 2 (DM2) obese aged (30-62) years. The body mass index (BMI) of those patients was ≥ 30 kg/m and compared to 2 groups: the first included 20 people who are non-diabetic non-obese of age (30-75) years and the second included 26 people who are non-diabetic obese with ages (22-67) years. The level of adiponectin in patients and both control groups was measured. The results showed a significant decrease in adiponectin when compared to DM2 obese and non-diabetic non-obese, while non-significant decrease were found when compared to non-diabetic type 2 obese. The results of the percentage of DNA damage of lymphocytes in patients when using comet assay test have been found to be significance (P< 0.05) in DM2 obese using Tail Mean Moment and Tail Length (Px) parameters when compared to both control groups. Also the results showed high significance (P< 0.05) in other parameters such as Olive Moment, DNA in Head (%) and DNA in Tail (%) in type2 diabetic obese group as compared to non-diabetic non-obese group.