Study the anti-leukotrienic effect of watery suspension of Nigella sativa Linn. seeds in mice

  • W. H. Al-Shebani, and F. J.l Al-Tahan Coll. of Vet. Med. / Univ. of Al-Qadisiyah


The present study was designed to investigate the anti-inflammatory properties of
the watery suspension of powdered Nigella sativa seeds. This action was demonstrated
by anti-leukotrienic activity in skin of mice. Leukotrien inhibition was reflected by
reduction in skin scratching numbers, reduction the increment in skin thickness and
diminution of histopathological changes at the site of leukotriene B4 injection..
Reduction magnitudes of these parameters after Nigella seeds suspension administration
approximated those observed in mice treated orally with dexamethasone ,intradermally
preinjected with Leukotriene B4. Reduction in Leukotriene activity led to reduction of
inflammatory magnitude due to direct effect of Nigella sativa on Leukotriene and
probably on other chemical mediators.