Role of Vitamin E-Selenium in ameliorating sub chronic cadmium sulfate toxicity in rabbits

  • May J. Abd Coll. of Vet. Med. / Univ. of Al-Qadisiyah


The study aims to evaluate the ameliorating role of vitamin E-selenium supplementation on serum chemistry and histopathological alterations of liver and heart in rabbits caused by subchronic cadmium sulfate toxicity. Twenty white NewZealand rabbits of six months old were used and they divided into two groups' ten animals of each. G1 given cadmium sulfate 250mg/L in drinking water, G2 was supplemented with cadmium sulfate 250 mg/L plus vitamin E-selenium 500mg/L daily for 60 days. The results show vitamin E-selenium were significantly improved (P≤0.01) serum ALT, AST, bilirubin, alkaline phosphate, GGT and total protein, while total cholesterol, TG, HDL, LDL, VLDL had some improvement but they didn't reach significant value (P≥0.01), where no changes in the serum myoglobin, troponin and Ck-MP, and the histopathological examinations of liver were confirmed these results. in conclusion supplementation of vitamin E-selenium to the feed of rabbits exposed to the subchronic toxicity of cadmium sulfate reduce the effect of toxicity on the bioindicators of the liver in this study.