Toxic pathological effect of mitomycin-c on male reproductive organs in rat

  • Hala Abbas Naji Department of pathology and poultery diseases/College of Veterinary Medicine/ University of AL-Qadisiyah
  • Khalil Gazar Chelab Department of pathology and poultery diseases/College of Veterinary Medicine/ University of AL-Qadisiyah
  • Atiaf Ghanim Rhyaf Department of pathology and poultry diseases, College of Veterinary Medicine/ University of AL-Qadisiyah


The aim of present study was detected the effect of Mitomycin-c on the histological structure on male reproductive organ. In this study used (24) healthy adult male rats were divided into three groups, each group includes (8) animals: the 1st toxic group was injected (6.5mg/kg) of Mitomycin-c subcutaneous (s/c) once daily, the 2ed therapeutic or low dose group was injected (3.25 mg/kg) of Mitomycin-c subcutaneous (s/c) once daily, while the 3rd control group was injected physiological normal saline (0.9% NaCl2). The experimental period was (10) weeks. Animal, which were treated with Mitomycin-c along the period of experiment showed, sever pathological changes, particularly in testes and epididymis.


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