Effect of iron dextran injections on some synovia markers of Iraqi sport horses

  • Qayes Taref Ali Department of Veterinary Surgery and Obstetrics, College of Veterinary Medicine, University of Al-Qadisiyah, Iraq.

Abstract

   In the past decades, many veterinarians and trainers had been tried to use iron preparations as performance enhancers for racing, or for treatments such as ˝anemiȁ. The study was conducted on (12) Iraqi sport horses. The principal aims of the study were to investigate the effect of iron dextran on some synovial fluid constituents at the rest and the endurance exercise of Iraqi sports horses. The physical markers of synovial fluids of the sports horses which are included in this study, shows: (TG-1) (gallop and iron dextran treatment) are mostly slight turbid, dark yellow, very low viscid, and normal mucin clot formation. (TG-2) (Iron dextran only) are mostly clear, yellow, viscid and normal mucin clot formation. While (CG-3) (distil water only) are mostly clear, pale yellow, viscid and fair mucin clot formation. The effect of iron dextran on some biochemical markers of the synovial fluid constituents of the sports horses which included in the study were shows as in table-3: the PH value of (TG-1) was very low than normal 6.15±0.85 which was significantly different at P≤0.05 with the PH value of the (TG-2) 6.64±0.36 while the PH of (CG-3) was within normal value 7.57±0.85 and there was no significant different at P≤0.05 with (TG-2). The WBC value of (TG-1) was 8.61±0.38 (WBC/mm3) which was different significantly at P≤0.05 with (TG-2) 6.95±0.60 (WBC/mm3) but (TG-2) was not different significantly at P≤0.05 with (CG-3) 5.45±0.20. (WBC/mm3).The glucose value of (TG-1) was reduced than normal 52.89±1.58 (mg/dl), which was different significantly, at (P≤0.05) with (TG-2) 51.48±1.12 (mg/dl), but (TG-2) was not different significantly at (P≤0.05) with (CG-3) 53.14±1.04 (mg/dl). The total protein value of (TG-1) was increased than normal 3.68±0.38 (g/dl) which was different significantly at P≤0.05 with (TG-2) 2.45±0.23(g/dl)  but (TG-2) was not different significantly at (P≤0.05) with (CG-3) 1.52±0.21. (g/dl). The hyaluronic acid values were significantly different at P≤0.05 between all groups, (TG-1) 0.33±0.03 (mg/ml), (TG-2) 0.21±0.03 (mg/ml), and (CG-3) 0.37±0.03 (mg/ml) respectively. The alkaline phosphatase values also were significantly different at P≤0.05 between all groups, (TG-1) 38.44±1.61 (IU/L), (TG-2) 27.25±0.22 (IU/L), and (CG-3) 25.31±1.79 (IU/L), respectively. In conclusion, iron injections had no any improvement to the sport horses' synovia.

References

1-Bahatti R, Shaikh DM. The effect of exercise on blood parameters. Pakistan Journal of Physiology; (2007); 3(2)44-46.
2-McIIwraith CW. Use of synovial fluid and serum biomarkers in equine bone and joint disease: a review. Equine Veterinary Journal;(2005);37:473-482.
3-Iwanaga T, Shikichi M, Kitamura H, Yanase H, Nozawa-Inoue K. Morphology and functional roles of synoviocytes in the joint. Arch. Histo. Cytol. (2000); 63:17-31
4-Punzi L, Oliviero F, Plebani M. New biochemical insights into the pathogenesis of osteoarthritis and the role of laboratory investigations in clinical assessment. Crit. Rev. Clin. Lab. Sci. (2005); 42:279-309.
5-MacDonald MH, Tesh AM, Benton HP. Willits NH. Characterization of age and location- associated variations in the composition of articular cartilage from the metacarpophalangeal joint. J.Eq.Vet.Sci. (2002); 22:25-32.
6-Jovanovic M, IIlic V, Trailovic D, Durdevic D. The role of different iron preparations in the prevention of anemia in racing horse; (2007);57(4)357-368.
7-Towfik AI. The effect of running at many speeds on some synovial fluid constituents in Iraqi Arabian horses. Al-Qadissiya Journal of Veterinary Med.Sci. (2015);14(1)39-43.
8-Kind CN, Blackham A, Morris CJ. Effect of intravenous iron-dextran (Imferon) infusion on antigen induced monarticular arthritis in rabbits. Annals of the Rheumatic Diseases.(1992); 51:1237-1241
9-Blackham A, Farmer JB, Radziwonik H, Westwick J. The role of prostaglandins in rabbit monarticular arthritis. Br.J.Pharmacol. (1974);51:35-44.
10-Bashandy MM, Ibrahim AK, El-Olemy KA, El- Ghoul WS, Morgan HM. Clinicopathological, radiological and synovial fluid evaluations in common musculoskeletal affections in horses. Global Veterinaria.(2014);13(5):889-897.
11-McIlwraith CW. Use of sodium hyaluronate (Hyaluronan) in equine joint disease. Equine Veterinary Education. (1997); 9(6):296-304.
12-Amir I, Towfik Abdul-Shaheed HG, Munahi AK. Effect of iron injections and exercise on some blood parameters and wound bleeding in Iraqi Arabian horses. Kufa Journal for Veterinary Medical Sciences. (2016);7(2):204-210.
Published
2017-11-11
How to Cite
ALI, Qayes Taref. Effect of iron dextran injections on some synovia markers of Iraqi sport horses. AL-Qadisiyah Journal of Veterinary Medicine Sciences, [S.l.], v. 16, n. 1, p. 46-50, nov. 2017. ISSN 2313-4429. Available at: <http://qu.edu.iq/journalvm/index.php/vm_journal/article/view/34>. Date accessed: 24 june 2018. doi: https://doi.org/10.29079/vol16iss1art34.